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Ipamorelin and GHRP-6 are both ghrelin mimetics that stimulate GH release via the GHSR-1a receptor, but their selectivity profiles differ significantly. Ipamorelin is highly selective — research demonstrates GH release with minimal effects on cortisol, prolactin or ACTH at standard research concentrations. GHRP-6 research shows stronger GH release amplitude but with accompanying cortisol and prolactin elevations in research models. This selectivity difference makes Ipamorelin the preferred compound in research protocols where isolated GH axis effects are required, while GHRP-6 is studied when broader ghrelin receptor activation effects are relevant. Published research comparing both compounds has examined GH pulse amplitude and frequency, IGF-1 responses, appetite regulation (GHRP-6 shows stronger appetite-stimulating effects), and downstream metabolic parameters. The choice between compounds depends entirely on the specific research protocol being conducted.
