NAD+ and Longevity Research: What the Science Says

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme involved in hundreds of metabolic reactions and a substrate for key longevity-associated enzymes including sirtuins and PARPs. Research has demonstrated that NAD+ levels decline with age in multiple tissues. Studies examining NAD+ precursor supplementation and its effects on sirtuin activity, mitochondrial function and DNA repair mechanisms have generated considerable scientific interest. Research continues to examine the relationship between NAD+ bioavailability and age-related biology.