Research
MOTS-c: Mitochondrial Derived Peptide Research Overview
"MOTS-c is a mitochondria-encoded peptide with emerging research interest in metabolism and longevity biology."
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) was identified by researchers at USC in 2015. Encoded within the mitochondrial genome, MOTS-c research has examined its role as a metabolic regulator that activates AMPK signalling, improves insulin sensitivity and modulates exercise adaptation in research models. Studies have also explored its potential role in longevity biology and age-related metabolic decline.
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